Article
Strategies for the Enantioselective Synthesis of Spirooxindoles
Organic and Biomolecular Chemistry
(2012)
Abstract
Oxindoles and spirooxindoles are important synthetic targets that are often considered to be prevalidated with respect to their biological activity and applications for pharmaceutical lead discovery. This review features efficient strategies for the enantioselective synthesis of spirocyclic oxindoles, focusing on reports in 2010 and 2011. Although enantioselective synthesis remains an ongoing challenge, exciting recent advances in this area feature spirooxindoles with greater complexity, up to eight stereogenic centers, more practical synthetic methods, and new catalytic activation strategies. Developments in catalyst systems and reaction conditions have shown that many reactions can be optimized to control selectivity and provide access to isomeric products, which are important for biological testing. This review is organized based on two primary disconnection strategies, and then further subdivided into the type and ring size of the spirocycle that is generated. Strategies are also compared for the synthesis of non-spirocyclic 3,3′-disubstituted oxindoles.
Disciplines
Publication Date
July 21, 2012
DOI
10.1039/C2OB25184A
Citation Information
Nicolas R. Ball-Jones, Joseph Badillo and Annaliese K. Franz. "Strategies for the Enantioselective Synthesis of Spirooxindoles" Organic and Biomolecular Chemistry Iss. 27 (2012) p. 5165 - 5181 ISSN: 1477-0539 Available at: http://works.bepress.com/joseph-badillo/4/