Article
Metabolites from the Marine-Derived Fungus Chromocleista sp. Isolated from a Deep-Water Sediment Sample Collected in the Gulf of Mexico
Journal of Natural Products
ORCID
0000-0002-1637-4125
ResearcherID
F-8809-2011
Document Type
Article
Publication Date
1-1-2006
Keywords
- Ascomycota,
- Candida albicans,
- Leukemia P388,
- Microbial Sensitivity Tests,
- Pyrroles,
- Molecular Structure
Abstract
As part of our ongoing chemical investigation of biologically active metabolites from marine fungi, three new compounds, p-hydroxyphenopyrrozin (1) and diketopiperazines (3, 4), have been isolated from the marine-derived fungus Chromocleista sp. In addition, the fungus gave the known compound phenopyrrozin (2), four known diketopiperazines (6-9), N-acetyltryptamine (10), and agathic acid (11). Another new diketopiperazine (5) was separated and identified as a decomposition product of 3 and 4. The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies.
DOI
10.1021/np058113p
Disciplines
Citation Information
Park, Young Chul, Sarath P. Gunasekera, Jose V. Lopez, Peter J. McCarthy, and Amy E. Wright. "Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico." Journal of natural products 69, no. 4 (2006): 580-584.
©2006 American Chemical Society and American Society of Pharmacognosy