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Selected Works of Jose V. Lopez
Article
Diverse Bacterial PKS Sequences Derived from Okadaic Acid-Producing Dinoflagellates
Marine Drugs
  • Roberto Perez, Florida International University
  • Li Liu, Florida International University
  • Jose V. Lopez, Nova Southeastern University
  • Tianying An, Florida International University
  • Kathleen S. Rein, Florida International University
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ORCID
0000-0002-1637-4125
ResearcherID
F-8809-2011
Document Type
Article
Publication Date
1-1-2008
Keywords
  • Okadaic acid,
  • Polyketide,
  • Polyketide synthase,
  • Biosynthesis,
  • Roseobacter
Abstract

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

DOI
10.3390/md20080009
Comments

©2008 by the author(s); licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Additional Comments
National Institute of Environmental Health Sciences grant #s: S11 ES11181, P50 ES12736-01; NSF grant #: 0432368; USDA grant #: NRICGP 2002-35201-11671
Disciplines
Citation Information
Perez, Roberto, Li Liu, Jose Lopez, Tianying An, and Kathleen S. Rein. "Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates." Marine drugs 6, no. 2 (2008): 164-179.