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Article
Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction
GSBS Student Publications
  • Hoa L. Nguyen, University of Massachusetts Medical School
  • Jane S. Saczynski, University of Massachusetts Medical School
  • Joel M. Gore, University of Massachusetts Medical School
  • Molly E. Waring, University of Massachusetts Medical School
  • Darleen M. Lessard, University of Massachusetts Medical School
  • Jorge L. Yarzebski, University of Massachusetts Medical School
  • George W. Reed, University of Massachusetts Medical School
  • Frederick A. Spencer, McMaster University
  • Shu-Xia Li, Yale-New Haven Hospital
  • Robert J. Goldberg, University of Massachusetts Medical School
Student Author(s)
Hoa L. Nguyen
GSBS Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine; Department of Quantitative Health Sciences
Date
10-1-2011
Document Type
Article
Medical Subject Headings
Myocardial Infarction; Hospital Mortality; Hospitalization; Sex Factors; Age Factors; Treatment Outcome
Abstract
BACKGROUND: The objectives of this study were to examine the magnitude of, and 20-year trends in, age differences in short-term outcomes among men and women hospitalized with acute myocardial infarction (AMI) in central Massachusetts. METHODS: The study population consisted of 5907 male and 4406 female residents of the Worcester, MA, metropolitan area hospitalized at all greater Worcester medical centers with AMI between 1986 and 2005. RESULTS: Overall, among both men and women, older patients were significantly more likely to have developed atrial fibrillation, heart failure, and to have died during hospitalization and within 30 days after admission compared with patients agedmen, age differences in the risk of developing atrial fibrillation have widened over the past 2 decades, while differences in the risk of developing cardiogenic shock have narrowed for men 75 years and older as compared with those agedwomen, age differences in the risk of developing these major complications of AMI have not changed significantly over time. Age differences in short-term mortality have remained relatively unchanged over the past 20 years in both sexes, although individuals of all ages have experienced decreases in short-term death rates over this period. CONCLUSIONS: Elderly men and women are more likely to experience adverse short-term outcomes after AMI, and age differences in short-term mortality rates have remained relatively unchanged in both sexes over the past 20 years. More targeted treatment approaches during hospitalization for AMI and thereafter are needed for older patients to improve their prognosis.
Comments

Citation: Am J Med. 2011 Oct;124(10):939-46. Link to article on publisher's website

Related Resources
Link to article in PubMed
Keywords
  • UMCCTS funding
PubMed ID
21962314
Citation Information
Hoa L. Nguyen, Jane S. Saczynski, Joel M. Gore, Molly E. Waring, et al.. "Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction" Vol. 124 Iss. 10 (2011) ISSN: 1555-7162
Available at: http://works.bepress.com/jorge_yarzebski/84/