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Article
Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective
Open Access Articles
  • Robert J. Goldberg, University of Massachusetts Medical School
  • Frederick A. Spencer
  • Joel M. Gore, University of Massachusetts Medical School
  • Darleen M. Lessard, University of Massachusetts Medical School
  • Jorge L. Yarzebski, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine
Date
2-25-2009
Document Type
Article
Subjects
Aged; Female; Hospital Mortality; Hospitals, Community; Hospitals, Teaching; Hospitals, Urban; Humans; Incidence; Male; Massachusetts; Myocardial Infarction; Prognosis; Risk Factors; Shock, Cardiogenic
Abstract

BACKGROUND: Limited information is available about potentially changing and contemporary trends in the incidence and hospital death rates of cardiogenic shock complicating acute myocardial infarction. The objectives of our study were to examine 3-decade-long trends (1975 to 2005) in the incidence rates of cardiogenic shock complicating acute myocardial infarction, patient characteristics and treatment practices associated with this clinical complication, and hospital death rates in residents of a large central New England community hospitalized with acute myocardial infarction at all area medical centers.

METHODS AND RESULTS: The study population consisted of 13 663 residents of the Worcester (Mass) metropolitan area hospitalized with acute myocardial infarction at all greater Worcester medical centers during 15 annual periods between 1975 and 2005. Overall, 6.6% of patients developed cardiogenic shock during their index hospitalization. The incidence rates of cardiogenic shock remained stable between 1975 and the late 1990s but declined in an inconsistent manner thereafter. Patients in whom cardiogenic shock developed had a significantly greater risk of dying during hospitalization (65.4%) than those who did not develop cardiogenic shock (10.6%) (P<0.001). Encouraging increases in hospital survival in patients with cardiogenic shock, however, were observed from the mid-1990s to our most recent study years. Several patient demographic and clinical characteristics were associated with an increased risk for developing cardiogenic shock.

CONCLUSIONS: Our findings indicate improving trends in the hospital prognosis associated with cardiogenic shock. Given the high death rates associated with this clinical complication, monitoring future trends in the incidence and death rates and the factors associated with an increased risk for developing cardiogenic shock remains warranted.

Rights and Permissions
Citation: Circulation. 2009 Mar 10;119(9):1211-9. Epub 2009 Feb 23. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
19237658
Citation Information
Robert J. Goldberg, Frederick A. Spencer, Joel M. Gore, Darleen M. Lessard, et al.. "Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective" Vol. 119 Iss. 9 (2009) ISSN: 0009-7322 (Linking)
Available at: http://works.bepress.com/jorge_yarzebski/75/