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Article
Thirty-year trends (1975-2005) in the magnitude, patient characteristics, and hospital outcomes of patients with acute myocardial infarction complicated by ventricular fibrillation
Quantitative Health Sciences Publications and Presentations
  • Robert J. Goldberg, University of Massachusetts Medical School
  • Jorge L. Yarzebski, University of Massachusetts Medical School
  • Frederick A. Spencer, McMaster University
  • Juan Carlos Zevallos, University of Puerto Rico
  • Darleen M. Lessard, University of Massachusetts Medical School
  • Joel M. Gore, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine
Publication Date
12-10-2008
Document Type
Article
Subjects
Aged; Female; Hospital Mortality; Hospitalization; Humans; Incidence; Longitudinal Studies; Male; Massachusetts; Middle Aged; Myocardial Infarction; Prognosis; Treatment Outcome; Ventricular Fibrillation
Abstract

Limited contemporary data are available describing the incidence rates, hospital prognosis, and factors associated with the occurrence of ventricular fibrillation (VF) in patients hospitalized with acute myocardial infarction (AMI). The objectives of our study were to examine 3-decade-long trends (1975 to 2005) in the magnitude, predictors, and hospital case-fatality rates associated with VF in residents of a large New England metropolitan area hospitalized at all area medical centers with an uncomplicated AMI. The study population consisted of 7,472 residents of the Worcester (Massachusetts) metropolitan area hospitalized with an uncomplicated AMI in 15 annual periods from 1975 to 2005. The overall proportion of patients who developed VF was 4.2%. The incidence rates of VF remained stable from 1975 to 1995 but decreased thereafter, reaching their lowest frequency in 2005 (1.9%). Hospital case-fatality rates were significantly higher in patients with (40.9%) compared with those without (2.5%) VF. Decreases in hospital death rates over time were observed in patients with and without VF, with the decreases in death rates being greater for patients with VF. Patients who developed a Q-wave MI or a left or right bundle branch block were at particularly increased risk for developing VF. In conclusion, our results indicate that the incidence and hospital death rates associated with VF have decreased during recent years.

DOI of Published Version
10.1016/j.amjcard.2008.08.008
Source
Am J Cardiol. 2008 Dec 15;102(12):1595-601. Epub 2008 Sep 27. Link to article on publisher's site
PubMed ID
19064011
Related Resources
Link to Article in PubMed
Citation Information
Robert J. Goldberg, Jorge L. Yarzebski, Frederick A. Spencer, Juan Carlos Zevallos, et al.. "Thirty-year trends (1975-2005) in the magnitude, patient characteristics, and hospital outcomes of patients with acute myocardial infarction complicated by ventricular fibrillation" Vol. 102 Iss. 12 (2008) ISSN: 0002-9149 (Linking)
Available at: http://works.bepress.com/jorge_yarzebski/71/