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Article
Trends (1986 to 1999) in the incidence and outcomes of in-hospital stroke complicating acute myocardial infarction (The Worcester Heart Attack Study)
Quantitative Health Sciences Publications and Presentations
  • Frederick A. Spencer, McMaster University
  • Joel M. Gore, University of Massachusetts Medical School
  • Jorge L. Yarzebski, University of Massachusetts Medical School
  • Darleen M. Lessard, University of Massachusetts Medical School
  • Elizabeth A. Jackson, University of Michigan
  • Robert J. Goldberg, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine
Date
8-14-2003
Document Type
Article
Medical Subject Headings
Aged; Female; Hospital Mortality; *Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Risk Factors; Stroke
Abstract
Although stroke is an infrequent hospital complication of acute myocardial infarction (AMI), limited contemporary data are available about the incidence and death rates associated with this serious complication. The objective of this population-based study was to examine temporal trends (1986 to 1999) in the risk of stroke and associated hospital outcomes in patients hospitalized with AMI. This was an observational study of 6,325 metropolitan Worcester, Massachusetts, residents hospitalized with validated AMI and without prior stroke at all greater Worcester hospitals during 8 one-year periods between 1986 and 1999. Overall, 1.5% of patients (n = 92) with confirmed AMI developed an acute stroke during their index hospitalization. Decreases, followed by increases, in the risk of acute stroke were observed between 1986 and 1999. The highest risk for stroke was observed in the most recent study year of 1999 (3.0%). Several demographic, medical history, and clinical characteristics were associated with an increased risk of stroke overall and separately in younger and older patients hospitalized with AMI. Patients developing an acute stroke had a significantly increased risk of dying during hospitalization even after controlling for other factors of prognostic importance (adjusted odds ratio 4.26, 95% confidence interval 2.49 to 7.31). The results of this community-wide study provide insights into recent trends in the development of acute stroke after AMI and into the profile of high-risk patients.
Rights and Permissions
Citation: Am J Cardiol. 2003 Aug 15;92(4):383-8.
Related Resources
Link to Article in PubMed
Citation Information
Frederick A. Spencer, Joel M. Gore, Jorge L. Yarzebski, Darleen M. Lessard, et al.. "Trends (1986 to 1999) in the incidence and outcomes of in-hospital stroke complicating acute myocardial infarction (The Worcester Heart Attack Study)" Vol. 92 Iss. 4 (2003) ISSN: 0002-9149 (Linking)
Available at: http://works.bepress.com/jorge_yarzebski/1/