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Article
Murine spleen tissue regeneration from neonatal spleen capsule requires lymphotoxin priming of stromal cells
Journal of Immunology (2014)
  • Jonathan Tan
  • Takeshi Watanabe
Abstract
Spleen is a tissue with regenerative capacity, which allows autotransplantation of human spleen fragments to counteract the effects of splenectomy. We now reveal in a murine model that transplant of neonatal spleen capsule alone leads to the regeneration of full spleen tissue. This finding indicates that graft-derived spleen stromal cells, but not lymphocytes, are essential components of tissue neogenesis, a finding verified by transplant and regeneration of Rag1KO spleen capsules.We further demonstrate that lymphotoxin and lymphoid tissue inducer cells participate in two key elements of spleen neogenesis, bulk tissue regeneration and white pulp organization, identifying a lymphotoxin-dependent pathway for neonatal spleen regeneration that contrasts with previously defined lymphotoxin-independent embryonic spleen organogenesis.
Publication Date
2014
Citation Information
Jonathan Tan and Takeshi Watanabe. "Murine spleen tissue regeneration from neonatal spleen capsule requires lymphotoxin priming of stromal cells" Journal of Immunology Vol. 193 Iss. 3 (2014)
Available at: http://works.bepress.com/jonathan_tan/6/