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Article
Characterisation of the effect of LPS on DC subset discrimination in spleen.
Journal of Cellular and Molecular Medicine (2014)
  • Kristin Griffiths, Australian National University
  • Jonathan Tan, Australian National University
  • Helen O'Neill, Australian National University
Abstract
The Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is a potent inflammatory mediator and a leading cause of bacterial sepsis. While LPS is known to activate antigen-presenting cells, here we find that LPS down-regulates expression of CD11c and CD11b on splenic dendritic cell subsets, thus confounding the ability to identify these subsets following treatment. This has implications with regard to tracking the response to LPS in terms of the cell subsets involved, and should be considered whenever such studies are undertaken.
Keywords
  • dendritic,
  • cell,
  • lipopolysaccharide,
  • spleen
Publication Date
2014
Publisher Statement
© Copyright, The Authors, 2014 =Creative Commons 4.0 License
Citation Information
Kristin Griffiths, Jonathan Tan and Helen O'Neill. "Characterisation of the effect of LPS on DC subset discrimination in spleen." Journal of Cellular and Molecular Medicine Vol. 18 Iss. 9 (2014)
Available at: http://works.bepress.com/jonathan_tan/2/