The purpose of this study was to gain a more holistic view of the association between depression and visual functioning by examining possible mediating and moderating factors. Previous research has established a linkage between low life satisfaction and coping skills and depressive symptoms. Results of this study contribute to this literature by indicating that life satisfaction partially mediates the relationship between visual functioning and depression. Furthermore, a significant coping by visual functioning interaction was discovered, revealing that among this sample, visual impairment is associated with higher levels of depression among individuals with low coping skills; however, little effect was found for individuals with high coping skills. Results provide support for the importance of early screening of satisfaction with life and coping among older individuals experiencing age-related visual impairment.