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Non-24-hour sleep–wake syndrome following a car accident
Neurology (2003)
  • Jonathan Bruce Santo
The authors report the case of a 39-year-old sighted woman who displayed non-24-hour sleep–wake cycles following a car accident. The phase relationship between endogenous circadian markers such as plasma melatonin and 6-sulfatoxymelatonin rhythms and self-selected sleep times was abnormal. A laboratory investigation indicated that she was sensitive to bright light as a circadian synchronizer. MRI and brain CT scans were normal, but microscopic brain damage in the vicinity of the suprachiasmatic nucleus or its output pathways is plausible. 
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Jonathan Bruce Santo. "Non-24-hour sleep–wake syndrome following a car accident" Neurology (2003)
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