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Natural variation in gestational cortisol is associated with patterns of growth in marmoset monkeys (Callithrix geoffroyi)
General and Comparative Endocrinology
  • Aaryn C. Mustoe, University of Nebraska at Omaha
  • Andrew K. Birnie, University of Nebraska at Omaha
  • Andrew V. Korgan, University of Nebraska at Omaha
  • Jonathan Bruce Santo, University of Nebraska at Omaha
  • Jeffrey French, University of Nebraska at Omaha
Document Type
Article
Publication Date
2-1-2012
Disciplines
Abstract
High levels of prenatal cortisol have been previously reported to retard fetal growth. Although cortisol plays a pivotal role in prenatal maturation, heightened exposure to cortisol can result in lower body weights at birth, which have been shown to be associated with adult diseases like hypertension and cardiovascular disease. This study examines the relationship between natural variation in gestational cortisol and fetal and postnatal growth in marmoset monkeys. Urinary samples obtained during the mother’s gestation were analyzed for cortisol. Marmoset body mass index (BMI) was measured from birth through 540 days in 30- or 60-day intervals. Multi-level modeling was used to test if marmoset growth over time was predicted by changes in gestational cortisol controlling for time, sex, litter, and litter size. The results show that offspring exposed to intra-uterine environments with elevated levels of cortisol had lower linear BMI rates of change shortly after birth than did offspring exposed to lower levels of cortisol, but exhibited a higher curvilinear growth rate during adolescence. Average daily change in gestational cortisol during the first trimester had a stronger relationship with postnatal growth than change during the third trimester. Higher exposure to cortisol during gestation does alter developmental trajectories, however there appears to be a catch-up period during later post-natal growth. These observations contribute to a larger discussion about the relationship of maternal glucocorticoids on offspring development and the possibility of an earlier vulnerable developmental window.
Comments

NOTICE: this is the author’s version of a work that was accepted for publication in General and Comparative Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in General and Comparative Endocrinology, Vol. 3, Issue 1 (February 2012) DOI# 10.1016/j.ygcen.2011.12.020.

Citation Information
Aaryn C. Mustoe, Andrew K. Birnie, Andrew V. Korgan, Jonathan Bruce Santo, et al.. "Natural variation in gestational cortisol is associated with patterns of growth in marmoset monkeys (Callithrix geoffroyi)" General and Comparative Endocrinology Vol. 3 Iss. 1 (2012) p. 519 - 526
Available at: http://works.bepress.com/jonathan_santo/19/