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EFN-4 Functions in LAD-2-mediated Axon Guidance in Caenorhabditis elegans
  • Alicia A. Schwieterman, Kennesaw State University
  • Cory J. Donelson, Kennesaw State University
  • Jonathan L. McMurry, Kennesaw State University
  • Martin L. Hudson, Kennesaw State University
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During development of the nervous system, growing axons rely on guidance molecules to direct axon pathfinding. A well-characterized family of guidance molecules are the membrane-associated ephrins, which together with their cognate Eph receptors, direct axon navigation in a contact-mediated fashion. InC. elegans, the ephrin-Eph signaling system is conserved and is best characterized for their roles in neuroblast migration during early embryogenesis. This study demonstrates a role for theC. elegansephrin EFN-4 in axon guidance. We provide both genetic and biochemical evidence that is consistent with theC. elegansdivergent L1 cell adhesion molecule LAD-2 acting as a non-canonical ephrin receptor to EFN-4 to promote axon guidance. We also show that EFN-4 probably functions as a diffusible factor because EFN-4 engineered to be soluble can promote LAD-2-mediated axon guidance. This study thus reveals a potential additional mechanism for ephrins in regulating axon guidance and expands the repertoire of receptors by which ephrins can signal.
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Alicia A. Schwieterman, Cory J. Donelson, Jonathan L. McMurry and Martin L. Hudson. "EFN-4 Functions in LAD-2-mediated Axon Guidance in Caenorhabditis elegans" Development Vol. 143 Iss. 7 (2016) p. 1182 - 1191 ISSN: 1477-9129
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