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Biophotonic logic devices based on quantum dots and temporally-staggered Forster energy transfer relays
Nanoscale (2013)
  • Jonathan C. Claussen
  • W. Russ Algar, University of British Columbia
  • Niko Hildebrandt
  • Kimihiro Susumu
  • Mario G. Ancona
  • Igor L. Medintz
Integrating photonic inputs/outputs into unimolecular logic devices can provide significantly increased functional complexity and the ability to expand the repertoire of available operations. Here, we build upon a system previously utilized for biosensing to assemble and prototype several increasingly sophisticated biophotonic logic devices that function based upon multistep Förster resonance energy transfer (FRET) relays. The core system combines a central semiconductor quantum dot (QD) nanoplatform with a long-lifetime Tb complex FRET donor and a near-IR organic fluorophore acceptor; the latter acts as two unique inputs for the QD-based device. The Tb complex allows for a form of temporal memory by providing unique access to a time-delayed modality as an alternate output which significantly increases the inherent computing options. Altering the device by controlling the configuration parameters with biologically based self-assembly provides input control while monitoring changes in emission output of all participants, in both a spectral and temporal-dependent manner, gives rise to two input, single output Boolean Logic operations including OR, AND, INHIBIT, XOR, NOR, NAND, along with the possibility of gate transitions. Incorporation of an enzymatic cleavage step provides for a set-reset function that can be implemented repeatedly with the same building blocks and is demonstrated with single input, single output YES and NOT gates. Potential applications for these devices are discussed in the context of their constituent parts and the richness of available signal.
  • enzymatic cleavage,
  • functional complexity,
  • organic fluorophores,
  • resonance energy transfer,
  • peptide,
  • chemistry,
  • fluorescence resonance energy transfer,
  • genetic procedures,
  • quantum dots,
  • Center for Bio/Molecular Science and Engineering,
  • Optical Sciences Division,
  • Electronics Sciences and Technology Division,
  • College of Science,
  • George Mason University,
  • Sotera Defense Solutions
Publication Date
Citation Information
Jonathan C. Claussen, W. Russ Algar, Niko Hildebrandt, Kimihiro Susumu, et al.. "Biophotonic logic devices based on quantum dots and temporally-staggered Forster energy transfer relays" Nanoscale Vol. 5 Iss. 24 (2013)
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