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Complex logic functions implemented with quantum dot bionanophotonic circuits
ACS Applied Materials and Interfaces (2014)
  • Jonathan C. Claussen
  • Niko Hildebrandt
  • Kimihiro Susumu
  • Mario G. Ancona
  • Igor L. Medintz
We combine quantum dots (QDs) with long-lifetime terbium complexes (Tb), a near-IR Alexa Fluor dye (A647), and self-assembling peptides to demonstrate combinatorial and sequential bionanophotonic logic devices that function by time-gated Förster resonance energy transfer (FRET). Upon excitation, the Tb-QD-A647 FRET-complex produces time-dependent photoluminescent signatures from multi-FRET pathways enabled by the capacitor-like behavior of the Tb. The unique photoluminescent signatures are manipulated by ratiometrically varying dye/Tb inputs and collection time. Fluorescent output is converted into Boolean logic states to create complex arithmetic circuits including the half-adder/half-subtractor, 2:1 multiplexer/1:2 demultiplexer, and a 3-digit, 16-combination keypad lock.
  • biocomputing,
  • Forster resonance energy transfer (FRET),
  • molecular logic,
  • quantum dot,
  • terbium,
  • lanthanide,
  • Center for Bio/Molecular Science and Engineering,
  • Optical Sciences Division,
  • Electronics Science and Technology Division,
  • College of Sciences,
  • George Mason University,
  • NanoBioPhotonics,
  • Sotera Defense Solutions
Publication Date
Citation Information
Jonathan C. Claussen, Niko Hildebrandt, Kimihiro Susumu, Mario G. Ancona, et al.. "Complex logic functions implemented with quantum dot bionanophotonic circuits" ACS Applied Materials and Interfaces Vol. 6 Iss. 6 (2014)
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