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Article
CTRP8 and CTRP9B are Novel Proteins that Hetero-oligomerize with C1q/TNF Family Members
Biochemical and Biophysical Research Communications (2009)
  • Jonathan M. Peterson, Johns Hopkins University School of Medicine
  • Zhikui Wei, Johns Hopkins University School of Medicine
  • G. William Wong, Johns Hopkins University School of Medicine
Abstract
C1q/TNF family comprises over thirty secreted multimeric proteins that play diverse and important roles in immune, endocrine, skeletal, neuronal, reproductive, sensory, and vascular systems. Here we describe two novel human C1q/TNF family members, designated as CTRP8 and CTRP9B. Both genes are absent in the mouse genome. CTRP8 is expressed predominantly in lung and testis. In addition to forming homotrimers, CTRP8 also forms heteromeric complexes with C1q-related factor (CRF). CRF is a secreted multimeric protein that forms heteromeric complexes with CTRP1, CTRP9, and CTRP10. Although human CTRRP9A and CTRP9B share 98% amino acid identity, they are encoded by distinct genes and are biochemically distinct. While CTRP9A is robustly secreted as a multimeric protein, CTRP9B requires physical association with CTRP9A or adiponectin for its secretion. We propose here that combinatorial association between C1q/TNF family members is a possible mechanism to generate an expanded repertoire of functionally distinct ligands with altered function and/or receptor specificity.
Keywords
  • C1qtnf,
  • adipokine,
  • C1q/tnf family,
  • crf,
  • ctrp9,
  • hetero-oligomer,
  • combinatorial association,
  • multimeric,
  • C1q-related factor
Disciplines
Publication Date
October 16, 2009
DOI
10.1016/j.bbrc.2009.08.014
Citation Information
Jonathan M. Peterson, Zhikui Wei and G. William Wong. "CTRP8 and CTRP9B are Novel Proteins that Hetero-oligomerize with C1q/TNF Family Members" Biochemical and Biophysical Research Communications Vol. 388 Iss. 2 (2009) p. 360 - 365 ISSN: 1090-2104
Available at: http://works.bepress.com/jonathan-peterson/15/