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Immunomodulatory Roles of CTRP3 in Endotoxemia and Metabolic Stress
Physiological Reports (2016)
  • Jonathan M. Peterson, John Hopkins University School of Medicine
  • Risa M. Wolf, Johns Hopkins University School of Medicine
  • Xia Lei, Johns Hopkins University School of Medicine
  • G. William Wong, Johns Hopkins University School of Medicine
C1q/TNF‐related protein 3 (CTRP3) is a secreted hormone that modulates hepatic glucose and lipid metabolism. Its circulating levels are reduced in human and rodent models of obesity, a metabolic state accompanied by chronic low‐grade inflammation. Recent studies have demonstrated an anti‐inflammatory role for recombinant CTRP3 in attenuating LPS‐induced systemic inflammation, and its deficiency markedly exacerbates inflammation in a mouse model of rheumatoid arthritis. We used genetic mouse models to explore the immunomodulatory function of CTRP3 in response to acute (LPS challenge) and chronic (high‐fat diet) inflammatory stimuli. In a sublethal dose of LPS challenge, neither CTRP3 deficiency nor its overexpression in transgenic mice had an impact on IL‐1β, IL‐6, TNF‐α, or MIP‐2 induction at the serum protein or mRNA levels, contrary to previous findings based on recombinant CTRP3 administration. In a metabolic context, we measured 71 serum cytokine levels in wild‐type and CTRP3 transgenic mice fed a high‐fat diet or a matched control low‐fat diet. On a low‐fat diet, CTRP3 transgenic mice had elevated circulating levels of multiple chemokines (CCL11, CXCL9, CXCL10, CCL17, CX3CL1, CCL22 and sCD30). However, when obesity was induced with a high‐fat diet, CTRP3 transgenic mice had lower circulating levels of IL‐5, TNF‐α, sVEGF2, and sVEGFR3, and a higher level of soluble gp130. Contingent upon the metabolic state, CTRP3 overexpression altered chemokine levels in lean mice, and attenuated systemic inflammation in the setting of obesity and insulin resistance. These results highlight a context‐dependent immunomodulatory role for CTRP3.
  • immunomodulatory roles,
  • CTRP3,
  • endotoxemia,
  • metabolic stress
Publication Date
March 20, 2016
Publisher Statement
© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This document was originally published in Physiological Reports.
Citation Information
Jonathan M. Peterson, Risa M. Wolf, Xia Lei and G. William Wong. "Immunomodulatory Roles of CTRP3 in Endotoxemia and Metabolic Stress" Physiological Reports Vol. 4 Iss. 5 (2016) p. 1 - 13 ISSN: 2051-817X
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Creative Commons License
This work is licensed under a Creative Commons CC_BY International License.