Article
Serum vitamin B12 and related 5-methyltetrahydrofolate-homocysteine methyltransferase reductase and cubilin genotypes predict neural outcomes across the Alzheimerʼs disease spectrum
The British Journal of Nutrition
Document Type
Article
Disciplines
Publication Version
Accepted Manuscript
Publication Date
7-28-2020
DOI
10.1017/S0007114520000951
Abstract
Epidemiological studies show mixed findings for serum vitamin B12 and both cognitive and regional volume outcomes. No studies to date have comprehensively examined, in non-supplemented individuals, serum B12 level associations with neurodegeneration, hypometabolism, and cognition across the Alzheimer's disease (AD) spectrum. Serum vitamin B12 was assayed from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Voxel-wise analyses regressed B12 levels against regional gray matter (GM) volume and glucose metabolism (p
Copyright Owner
The Authors
Copyright Date
2020
Language
en
File Format
application/pdf
Citation Information
K. E. McLiman, A. D. Collazo Martinez, Jonathan P. Mochel, Karin D. Allenspach, et al.. "Serum vitamin B12 and related 5-methyltetrahydrofolate-homocysteine methyltransferase reductase and cubilin genotypes predict neural outcomes across the Alzheimerʼs disease spectrum" The British Journal of Nutrition Vol. 124 Iss. 2 (2020) p. 135 - 145 Available at: http://works.bepress.com/jonathan-mochel/69/
This article has been published in a revised form in The British Journal of Nutrition. DOI: 10.1017/S0007114520000951. This version is free to view and download for private research and study only. Not for re-distribution or re-use. © The Authors. Posted with permission.