Article
Relative oral bioavailability of two amoxicillin – clavulanic acid formulations in healthy dogs: a pilot study
J Am Anim Hosp Assoc
(2019)
Abstract
The use of human generic amoxicillin-clavulanic acid formulations in veterinary medicine is currently lacking supportive evidence. This pilot study was conducted to determine preliminary pharmacokinetic parameters and relative oral bioavailability of a human generic and veterinary proprietary 4:1 amoxicillin-clavulanic acid formulation in healthy dogs to evaluate whether drug exposure was similar and to determine if further comparative investigation is warranted. Each dog received a single oral dose of each formulation containing 500 mg:125 mg of amoxicillin-clavulanic acid at two separate instances with a two-week washout period between product administration. Following drug administration, blood was collected at fixed times over 24 hours to measure plasma amoxicillin and clavulanic acid concentrations using liquid chromatography-mass spectrometry. There were no statistically significant differences between pharmacokinetic parameters of either formulation. Clavulanic acid showed both greater between-dog variation in drug exposure between formulations compared to amoxicillinand was observed to be more variable within the veterinary proprietary formulation. The average relative oral bioavailability was 98.2% (90% confidence interval of 114.4%) for amoxicillin and 152.6% (90% confidence interval of 189.9%) for clavulanic acid between formulations. This pilot investigation supports the need for future relative bioequivalence studies before commenting on product interchangeability.
Disciplines
Publication Date
February, 2019
DOI
10.5326/JAAHA-MS-6872
Citation Information
Jonathan P. Mochel. "Relative oral bioavailability of two amoxicillin – clavulanic acid formulations in healthy dogs: a pilot study" J Am Anim Hosp Assoc (2019) Available at: http://works.bepress.com/jonathan-mochel/54/