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Article
A Review of Relevant Therapeutic Targets for the Management of Congestive Heart Failure in Dogs: Present and Future Directions
Preprints
  • Jonathan P. Mochel, Iowa State University
Document Type
Article
Publication Version
Submitted Manuscript
Publication Date
1-1-2019
DOI
10.20944/preprints201903.0082.v1
Abstract

Congestive heart failure (CHF) is a major cause of morbidity and mortality with an increasing prevalence in human and canine populations. Similar to humans, overactivation of the renin-angiotensin aldosterone system is involved in the pathophysiology of CHF in dogs. Current therapeutic strategies for the management of canine CHF include the use of RAAS inhibitors, diuretics and inodilators. The present review summarizes data from our own research on the modulation of the renin-angiotensin cascade in dogs in dogs, together with new findings (including novel therapeutic targets) from the veterinary and the human literature.

Comments

This is a pre-print of the article Mochel, Jonathan. "A Review of Relevant Therapeutic Targets for the Management of Congestive Heart Failure in Dogs: Present and Future Directions." Preprints (2019). DOI: 10.20944/preprints201903.0082.v1. Posted with permission.

Creative Commons License
Creative Commons Attribution 4.0
Copyright Owner
The Author
Language
en
File Format
application/pdf
Citation Information
Jonathan P. Mochel. "A Review of Relevant Therapeutic Targets for the Management of Congestive Heart Failure in Dogs: Present and Future Directions" Preprints (2019)
Available at: http://works.bepress.com/jonathan-mochel/39/