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Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins
Anti-Cancer Agents in Medicinal Chemistry (2011)
  • Jonathan Arambula, The University of Texas at Austin
  • Christian Preihs, The University of Texas at Austin
  • Derric Borthwick, The University of Texas at Austin
  • Darren Magda, The University of Texas at Austin
  • Jonathan L. Sessler, The University of Texas at Austin
Abstract
Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimentaluse in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.
Keywords
  • Texaphyrin,
  • Reactive oxygen species,
  • Anticancer activity,
  • Mechanism of action,
  • Zinc,
  • Platinum delivery,
  • Alpha and beta core emitters,
  • Superoxide dismutase,
  • Amyotrophic Lateral Sclerosis (ALS),
  • Parkinson's Disease (PD),
  • Alzheimer's Disease (AD),
  • Hydroquinones,
  • Chronic Lymphocytic Leukemia (CLL),
  • Gd-oxalate-Gd bridging interactions,
  • NAD levels
Disciplines
Publication Date
February, 2011
DOI
10.2174/187152011795255894
Citation Information
Jonathan Arambula, Christian Preihs, Derric Borthwick, Darren Magda, et al.. "Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins" Anti-Cancer Agents in Medicinal Chemistry Vol. 11 Iss. 2 (2011) p. 222 - 232
Available at: http://works.bepress.com/jonathan-arambula/6/