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Article
Recent Developments in Texaphyrin Chemistry and Drug Discovery
Inorg. Chem (2013)
  • Christian Preihs, University of Texas at Austin
  • Jonathan Arambula, University of Texas at Austin
  • Darren Magda, Lumiphore, Inc.
  • Heeyeong Jeong, Yonsei University
  • Dongwon Yoo, Yonsei University
  • Jinwoo Cheon, Yonsei University
  • Zahid H. Siddik, The University of Texas M. D. Anderson Cancer Center
  • Jonathan L. Sessler, The University of Texas at Austin
Abstract
Texaphyrins are pentaaza expanded porphyrins with the ability to form stable complexes with a variety of metal cations, particularly those of the lanthanide series. In biological milieus, texaphyrins act as redox mediators and mediate the production of reactive oxygen species (ROS). In this review, newer studies involving texaphyrin complexes targeting several different applications in anticancer therapy are described. In particular, the preparation of bismuth and lead texaphyrin complexes as potential α-core emitters for radiotherapy is detailed, as are gadolinium texaphyrin functionalized magnetic nanoparticles with features that make them of interest as dual-mode magnetic resonance imaging contrast agents and as constructs with anticancer activity mediated through ROS-induced sensitization and concurrent hyperthermia. Also discussed are gadolinium texaphyrin complexes as possible carrier systems for the targeted delivery of platinum payloads.

Keywords
  • Drug Discovery,
  • Chemistry,
  • Inorganic chemistry,
  • Texaphyrin chemistry,
  • Texaphyrin
Disciplines
Publication Date
April 4, 2013
DOI
10.1021/ic400226g
Citation Information
Christian Preihs, Jonathan Arambula, Darren Magda, Heeyeong Jeong, et al.. "Recent Developments in Texaphyrin Chemistry and Drug Discovery" Inorg. Chem Vol. 52 Iss. 21 (2013) p. 12184 - 12192
Available at: http://works.bepress.com/jonathan-arambula/4/