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Lanthanide Nano-drums: A New Class of Molecular Nanoparticles for Potential Biomedical Applications
Faraday Discussions (2014)
  • Richard A. Jones, The University of Texas at Austin
  • Annie J. Gnanam, The University of Texas at Austin
  • Jonathan Arambula, The University of Texas at Austin
  • Jessica N. Jones, The University of Texas at Austin
  • Jagannath Swaminathan, The University of Texas at Austin
  • Xiaoping Yang, The University of Texas at Austin
  • Desmond Schipper, The University of Texas at Austin
  • Justin W. Hall, The University of Texas at Austin
  • Lauren J. DePue, The University of Texas at Austin
  • Yakhya Dieye, University of Malaya
  • Jamuna Vadivelu, University of Malaya
  • Don J. Chandler, Luminex
  • Edward M. Marcotte, The University of Texas at Austin
  • Jonathan L. Sessler, The University of Texas at Austin
  • Lauren I. R Ehrlich, The University of Texas at Austin
  • Katherine A. Brown, The University of Texas at Austin
Abstract
We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide “nano-drums” are homogeneous 4d–4f clusters approximately 25 to 30 Å in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.
Keywords
  • Chemistry,
  • Lanthanide nano-drums,
  • Biomedics,
  • Biomedical applications,
  • Molecular nanoparticles
Disciplines
Publication Date
December 8, 2014
DOI
10.1039/C4FD00117F
Citation Information
Richard A. Jones, Annie J. Gnanam, Jonathan Arambula, Jessica N. Jones, et al.. "Lanthanide Nano-drums: A New Class of Molecular Nanoparticles for Potential Biomedical Applications" Faraday Discussions Vol. 175 (2014) p. 241 - 255
Available at: http://works.bepress.com/jonathan-arambula/2/