Lanthanide Nano-drums: A New Class of Molecular Nanoparticles for Potential Biomedical ApplicationsFaraday Discussions (2014)
We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide “nano-drums” are homogeneous 4d–4f clusters approximately 25 to 30 Å in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.
- Lanthanide nano-drums,
- Biomedical applications,
- Molecular nanoparticles
Publication DateDecember 8, 2014
Citation InformationRichard A. Jones, Annie J. Gnanam, Jonathan Arambula, Jessica N. Jones, et al.. "Lanthanide Nano-drums: A New Class of Molecular Nanoparticles for Potential Biomedical Applications" Faraday Discussions Vol. 175 (2014) p. 241 - 255
Available at: http://works.bepress.com/jonathan-arambula/2/