In comparison with many areas of Christian ecumenism, communication between Catholics and Latter-day Saints is rare. This essay examines the relational history of Catholics and Latter-day Saints in the United States to identify interaction barriers and challenges and advance dialogue. Each church’s traditional stance on and historical approach to interfaith dialogue is explained, and principles facilitating ethical discussion are identified. This historical and theological knowledge is then applied in contemporary practice. A panel of six experts, three from each tradition, was convened to discuss their faith and its bearing on relationships between Catholics and Latter-day Saints. An analysis of the themes discussed points toward potential for improved inter-church relations. Within a context of genuine interest, mutual tolerance and appreciation, and openness to developing personal friendships, theological similarities and differences can be engaged together in faith.