Phonotaxis in female crickets exhibits variability. While some females respond to calling songs typical of the males’ (syllable periods, 50–70 ms), others only respond to calling songs with shorter or longer syllable periods, outside the range of males’ calling songs. Other females lack selectivity and respond to the full range of calling songs. Nanoinjection of histamine into the prothoracic ganglion decreases phonotactic selectivity. Nanoinjection of antihistamine has the reverse effect. Nanoinjection of Juvenile Hormone III increases phonotactic selectivity, while nanoinjection of chelethrine chloride blocks the effect of Juvenile Hormone III. This suggests that Juvenile Hormone III exerts its effects through a protein kinase C pathway. The effect of Latrunculin on selective females is currently being tested. Preliminary data suggest Latrunculin reduces the effect of Juvenile Hormone III. The L3 prothoracic interneuron in female crickets responds selectively to the syllable period of the male’s calling song and it has been proposed to be responsible for syllable period-selective responses during phonotaxis. If this is true, then L3s should show variable responses that parallel the phonotactic behavior. Preliminary findings show L3’s selective responses decrease as a result of histamine applications. Sequential application of Juvenile hormone III and PKC-inhibitor also decrease L3’s selectivity and supports the hypothesis that processing by L3 contributes to the syllable period selective phonotaxis observed in this species.