Skip to main content
Isoniazid-induced serum sickness: Report of case
Journal of the American Osteopathic Association
  • John P. Simelaro, Philadelphia College of Osteopathic Medicine
  • J. Dale
  • D. Guest
Document Type
Publication Date
An unusual case of isoniazid (INH)-induced serum sickness is reported. A review of the literature shows that one patient in five who are receiving INH will experience the development of antinuclear antibodies (ANA). A positive ANA test does not warrant discontinuation of INH unless symptoms of systemic lupus erythematosus are present.

This article was published in Journal of the American Osteopathic Association, Volume 80, Issue 5, Pages 348-349.

The published version is available at

Copyright © 1981.

Citation Information
John P. Simelaro, J. Dale and D. Guest. "Isoniazid-induced serum sickness: Report of case" Journal of the American Osteopathic Association Vol. 80 Iss. 5 (1981) p. 348 - 349
Available at: