Although Aspergillus is a ubiquitous fungus, infection of the pleura with A. fumigatus is uncommon. When the fungus acts as a pathogen, specific antifungal chemotherapy is called for. Amphotericin B is commonly used, but has had uneven results when used intravenously. A case of pleural aspergillosis successfully treated by amphotericin B administered intrapleurally is reported.
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