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Article
Identification of γ-Aminobutyric Acid-Like Immunoreactive Neurons in the Rat Cuneate Nucleus
Neuroscience Letters
  • Vickie R. Roettger
  • John C. Pearson, Wright State University - Main Campus
  • Melvyn D. Goldfinger, Wright State University - Main Campus
Document Type
Article
Publication Date
2-13-1989
Abstract
Neurons in the cuneate nucleus of the rat were examined for γ-aminobutyric acid-like immunoreactivity (GABA-LI) using antiserum raised against GABA-glutaraldehyde-keyhole limpet hemocyanin. GABA-LI neurons were analyzed for size, shape, and distribution and compared to Nissl-stained neurons. GABA-LI cell bodies were located at all rostral-caudal levels and were distributed randomly throughout the nucleus except at the level of the obex, where they were limited to the peripheral region of the cuneate nucleus. GABA-LI cell bodies had a significantly smaller mean cross-sectional area than the total cuneate neuronal population and comprised 21.5% of the total neuronal population as assessed with Nissl-staining. These results are consistent with the hypothesis that GABA is involved in processing somatosensory information in the rat dorsal column nuclei.
DOI
10.1016/0304-3940(89)90137-7
Citation Information
Vickie R. Roettger, John C. Pearson and Melvyn D. Goldfinger. "Identification of γ-Aminobutyric Acid-Like Immunoreactive Neurons in the Rat Cuneate Nucleus" Neuroscience Letters Vol. 97 Iss. 1-2 (1989) p. 46 - 50 ISSN: 0304-3940
Available at: http://works.bepress.com/john_pearson1/28/