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Identification of γ-Aminobutyric Acid-Like Immunoreactive Neurons in the Rat Cuneate Nucleus
Neuroscience Letters
  • Vickie R. Roettger
  • John C. Pearson, Wright State University - Main Campus
  • Melvyn D. Goldfinger, Wright State University - Main Campus
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Neurons in the cuneate nucleus of the rat were examined for γ-aminobutyric acid-like immunoreactivity (GABA-LI) using antiserum raised against GABA-glutaraldehyde-keyhole limpet hemocyanin. GABA-LI neurons were analyzed for size, shape, and distribution and compared to Nissl-stained neurons. GABA-LI cell bodies were located at all rostral-caudal levels and were distributed randomly throughout the nucleus except at the level of the obex, where they were limited to the peripheral region of the cuneate nucleus. GABA-LI cell bodies had a significantly smaller mean cross-sectional area than the total cuneate neuronal population and comprised 21.5% of the total neuronal population as assessed with Nissl-staining. These results are consistent with the hypothesis that GABA is involved in processing somatosensory information in the rat dorsal column nuclei.
Citation Information
Vickie R. Roettger, John C. Pearson and Melvyn D. Goldfinger. "Identification of γ-Aminobutyric Acid-Like Immunoreactive Neurons in the Rat Cuneate Nucleus" Neuroscience Letters Vol. 97 Iss. 1-2 (1989) p. 46 - 50 ISSN: 0304-3940
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