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Article
Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog
PLoS ONE (2010)
  • B B Gowen
  • M H Wong
  • D Larson
  • W Ye
  • K H Jung
  • E J Sefing
  • R Skirpstunas
  • D F Smee
  • John D Morrey, Utah State University
  • S W Schneller
Abstract
A growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World arenaviruses (NWA) phylogenetically segregate into clade B and require maximum biosafety containment facilities for their study. Tacaribe virus (TCRV) is a nonpathogenic member of clade B that is closely related to the VHF arenaviruses at the amino acid level. Despite this relatedness, TCRV lacks the ability to antagonize the host interferon (IFN) response, which likely contributes to its inability to cause disease in animals other than newborn mice.
Keywords
  • infection model,
  • tacaribe,
  • arena virus
Disciplines
Publication Date
January 1, 2010
Citation Information
Gowen, B. B., M. H. Wong, D. Larson, W. Ye, K. H. Jung, E. J. Sefing, R. Skirpstunas, D. F. Smee, J. D. Morrey, and S. W. Schneller. 2010. Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog. PLoS ONE 5. PMID20862280 PMCPMC2940843