A Porphyrin Increases Survival Time of Mice after Intracerebral Prion InfectionAntimicrobial Agents and Chemotherapy (2006)
AbstractPrion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
- prion infection
Publication DateJanuary 1, 2006
Citation InformationKocisko, D.A., W. S. Caughey, R.E. Race, G. Roper, B. Caughey, and J.D. Morrey 2006. A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrobial Agents and Chemotherapy 50: 759-61.