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A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection
Antimicrobial Agents and Chemotherapy (2006)
  • D. A. Kocisko
  • W. S. Caughey
  • R. E. Race
  • G. Roper
  • B. Caughey
  • John D. Morrey, Utah State University
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
  • porphyrin,
  • survival,
  • mice,
  • intracerebral,
  • prion infection
Publication Date
January 1, 2006
Citation Information
Kocisko, D.A., W. S. Caughey, R.E. Race, G. Roper, B. Caughey, and J.D. Morrey 2006. A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrobial Agents and Chemotherapy 50: 759-61.