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Article
Intraventricular Administration of Antivasopressin Serum Inhibits Retention in Mice
Peptides (1983)
  • Arthur P. Leccese, University of Louisville
  • John L. Isenhour, Kennesaw State University
Abstract
Elevations and decrements in the levels of the posterior pituitary hormone vasopressin result in facilitations and deficits in retention, respectively, in rats. Despite the frequent use of mice in studies of pharmacological influences on retention, there is a paucity of information regarting the role of endogenous peptides, particularly vasopressin, in the memory processes of mice. In the present experiment, mice suffering from acute inactivation of central vasopressin, induced by an immediately posttraining, 2 μl, intracerebroventricular injection of antivasopressin serum, displayed a retention deficit for passive avoidance training. The results of this experiment suggest that endogenous vasopressin modulates the memory processes of mice, as well as rats.
Keywords
  • Antivasopressin serum,
  • Vasopressin,
  • ICV injections,
  • Passive avoidance,
  • Mice
Disciplines
Publication Date
March, 1983
Citation Information
Arthur P. Leccese and John L. Isenhour. "Intraventricular Administration of Antivasopressin Serum Inhibits Retention in Mice" Peptides Vol. 4 Iss. 2 (1983)
Available at: http://works.bepress.com/john_isenhour/5/