Proponents of transgenderism offer a competing story of reality, epistemology, and anthropology vis-á-vis Scripture’s teaching that God made humanity in his image either male or female. If the transgender argument continues to take root in culture as it has begun to do so in the courts and legislatures, it will have devastating effects in both the church and the marketplace where Christians will be subjected to public criticism and further legal battles. This essay argues from a conservative Evangelical perspective, augmented by a biblically informed natural law moral point of view, that it is permissible for Christian employers to terminate employees on the basis of transgender identity, and that this perspective should be protected, rather than persecuted, by the state.