2007 - Present | Sokol Professor of Medicinal Chemistry and Director, the Sokol Institute of Pharmaceutical Life Sciences, Montclair State University ‐ Chemistry and Biochemistry | |
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Disciplines
Research Interests
Professional Service and Affiliations
Present | Member, American Society for Biochemistry and Molecular Biology | Present | Member, American Society of Parasitologists | Present | Member, Association for the Advancement of Science | Present | Member, International AIDS Society Member |
Honors and Awards
- • Elucidated the mechanism whereby phosphorylation of protein synthesis initiation eIF-2 leads to cessation of protein synthesis by interfering with GDP/GTP exchange. Critical regulatory mechanism in eukaryotic cells and in viral protein synthesis.
- • First to isolate, clone and patent the receptor for the immunosuppressive agents FK-506 and rapamycin.
- • Elucidated the mechanism of action of the immunosuppressant agent rapamycin. Demonstrated that rapamycin uniquely inhibits G1-S progression during the cell cycle
- • Established a program aimed at developing small molecule inhibitors of p38 MAP Kinase. Developed and progressed JNJ 67657 into clinical trials
- • Identified the role of p38 MAP kinase in toxoplasmosis infection, HIV infection and in epithelial-mesenchymal transition (EMT).
- • Defined the role of the filarial parasite (B. malayi) protein kinase, BmMPK1, in protecting the parasite from oxidative stress.
- Awarded the Johnson Medal, J & J’s highest award for scientific research and development.
- • Co-developed the rapamycin-eluting cornary stent. Directed the pharmacological & biochemical aspects of the program. Successfully led to the launch of the Cypher drug-eluting stent
1982 | PhD, New York University ‐ Biochemistry | |
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1974 | MS, City University of New York | |
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1971 | BS, Seton Hall University | |
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