Eighteen barrows with a T-cannula in the distal ileam were utilized in a study evaluating the impact of tylosin phosphate on amino acid and energy digestibility in cornsoybean meal and corn-soybean meal-distillers dried grains with soluble (DDGS) based diets. There were no interactions between the responses to tylosin phosphate and DDGS (P>0.10). DDGS inclusion reduced the standardized ileal digestibility of most indispensible amino acids (P<0.05) and the apparent ileal digestibility and apparent total tract digestibility of energy. Under the conditions of this experiment, tylosin phosphate did not affect digestibility of amino acids or energy and the inclusion of DDGS did not affect the response to TP.