Contribution to Book
23. Radioimmunotherapy and Hematopoietic Cell Transplantation
Thomas’ Hematopoietic Cell Transplantation: Stem Cell Transplantation, I
(2016)
Abstract
This chapter focuses on the clinical therapeutic aspects of targeted radionuclides for diagnosis and therapy of tumors. The current state of clinical use of RAbs and radiopeptides, and the state of development of new compounds and future innovations are reviewed. Discussion of preclinical studies is limited to those that offer insights into future directions for clinical study. The radioisotopes appropriate for diagnosis and therapy, and the radiolabeling methods that are currently in use are described. Appropriate target antigen selection is crucial if a favorable biodistribution of RAbs is to be achieved. MAb specificity and binding kinetics also play an important role in optimizing the biodistribution of RAbs. Retaining MAb immunoreactivity is essential during the physical process of radiolabeling and great care must be taken to maintain sterility. The exponential decline of radiation exposure seen with radioimmunotherapy is dependent on the chosen particle's half‐life of decay.
Keywords
- radioimmunotherapy,
- monoclonal antibody,
- biodistribution,
- dosimetry,
- radionuclides
Disciplines
Publication Date
January 1, 2016
Editor
Stephen J. Forman MD, Robert S. Negrin MD, Joseph H. Antin MD, Frederick R. Appelbaum MD,
Publisher
John Wiley & Sons, Ltd.
ISBN
9781118416006
DOI
10.1002/9781118416426.ch23
Publisher Statement
Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource.
- Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research
- Combines the knowledge and expertise of over 170 international specialists across 106 chapters
- Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance
- Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making
- Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more
References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.
Citation Information
John M. Pagel and Ajay K. Gopal. "23. Radioimmunotherapy and Hematopoietic Cell Transplantation" 5thOxfordThomas’ Hematopoietic Cell Transplantation: Stem Cell Transplantation, I (2016) p. 258 - 275 Available at: http://works.bepress.com/john-pagel/48/