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Selected Works of John M. Pagel, MD, PhD
Contribution to Book
Chronic Lymphocytic Leukemia (CLL)
Leukemia and Related Disorders: Integrated Treatment Approaches (2011)
  • Jonathan A. Gutman, University of Colorado Denver
  • Kelly M. Smith, University of Washington
  • John M. Pagel, University of Washington
Link
Abstract
Chronic lymphocytic leukemia is the most common leukemia affecting adults in Western countries, accounting for about 30% of all leukemias. It is a clonal malignancy of mature CD5+B-lymphocytes involving the peripheral blood, bone marrow, and lymphoid organs and has a distinct immunophenotype that allows differentiation from other B-cell lymphomas. Most patients with CLL present with a lymphocytosis at diagnosis; however, some patients present with lymphadenopathy alone. CLL is predominantly a disease of the elderly as the median age at diagnosis is 72 years. The clinical course of CLL is quite variable, with survival times from initial diagnosis ranging from 2 to 20 years.
Keywords
  • Chronic lymphocytic leukemia,
  • Leukemia,
  • Peripheral blood,
  • Bone marrow,
  • Lymphoid organs,
  • B-cell lymphoma,
  • Lymphocytosis,
  • Lymphadenopathy,
  • Elderly
Disciplines
Publication Date
November 26, 2011
Editor
Elihu H. Estey; Fred R. Appelbaum
Publisher
Springer
ISBN
978-1-60761-565-1
DOI
10.1007/978-1-60761-565-1_3
Publisher Statement
From the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia.  It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice.  In keeping with the Center’s groundbreaking  research in bone marrow transplantation, the book provides exceptional coverage of the role of allogeneic transplant in treatment.  It also addresses the important issues of supportive care and long-term complications of successful treatment. 
 
•Edited and written by experts at the Fred Hutchinson Cancer Research Center
•Clinically focused and comprehensive coverage of treatment approaches
•Allogeneic transplant addressed in detail
•Separate chapters on supportive care and long-term complications 
Citation Information
Jonathan A. Gutman, Kelly M. Smith and John M. Pagel. "Chronic Lymphocytic Leukemia (CLL)" New York, NYLeukemia and Related Disorders: Integrated Treatment Approaches (2011) p. 67 - 96
Available at: http://works.bepress.com/john-pagel/189/