This study presents a useful analytical method based on a statistical approach for optimizing the performance of Eco-selfconsolidating cement mixture (SCCM) (mortar component). Eco-SCCM is a new class of concrete mixtures that satisfies engineering design requirements (mechanical and rheological properties) and environmental concerns. Three different phases with a total of 43 mixtures were generated using commercially available software to study the effect of using high-volume fly ash on the performance of cement mixtures. Hydrated lime was added as the third component to increase the hydration activity of fly ash. Two different curing regimes were investigated. Fresh properties were measured, and hardened properties such as compressive strength, drying shrinkage, and surface resistivity were also monitored. The results of the phases were compared to track the effect of supplemental levels of fly ash and hydrated lime. To optimize the performance of Eco-SCCM, the desirability function approach was successfully applied. Results showed that mixtures with 37% portland cement Type I/II and 63% fly ash under a moist curing regime yielded the highest performance level.