Rehabilitation of existing structures with carbon fiber reinforced polymers (CFRP) has been growing in popularity because they offer resistance to corrosion and a high stiffness-to-weight ratio. This paper presents the flexural strengthening of seven reinforced concrete (RC) beams with two FRP systems. Two beams were maintained as unstrengthened control samples. Three of the RC beams were strengthened with CFRP fabrics, whereas the remaining two were strengthened using FRP precured laminates. Glass fiber anchor spikes were applied in one of the CFRP fabric strengthened beams. One of the FRP precured laminate strengthened beams was bonded with epoxy adhesive and the other one was attached by using mechanical fasteners. Five of the beams were tested under fatigue loading for two million cycles. All of the beams survived fatigue testing. The results showed that use of anchor spikes in fabric strengthening increase ultimate strength, and mechanical fasteners can be an alternative to epoxy bonded precured laminate systems.