Skip to main content
Article
mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score
The Veterinary Journal (2010)
  • Sara Roshwalb
  • Sarah Gorman
  • Sarah Hurst
  • Joe Bartges, DVM, PhD, DACVIM, DACVN, University of Tennessee - Knoxville
  • Sujata Agarwal
  • Carla Sommardahl
  • Agricola Odoi
  • Madhu S. Dhar
Abstract

Mouse and human Atp10c genes are strong candidates for changes in bodyweight and glucose homeostasis. Using comparative genomic analysis, a novel canine P4-type ATPase, ATP10C, was identified. Expression of ATP10C was compared between sex-matched lean (body condition score, BCS < 8; n = 7) and obese (BCS greater-or-equal, slanted 8, n = 8) client-owned dogs of comparable ages. Canine ATP10C is highly expressed in visceral and subcutaneous fat at approximately 3-fold levels compared to the omental adipose depot. There was a 5-fold significant increase (P < 0.0001) in mRNA expression of ATP10C in dogs with a BCS greater-or-equal, slanted 8.

Keywords
  • canine,
  • p-type ATPase,
  • genomics,
  • insulin resistance
Disciplines
Publication Date
2010
Citation Information
Sara Roshwalb, Sarah Gorman, Sarah Hurst, Joe Bartges, et al.. "mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score" The Veterinary Journal (2010)
Available at: http://works.bepress.com/joe_bartges/88/