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Canine urate urolithiasis
Veterinary Clinic North American Small Animal Practice (1999)
  • Joe Bartges, DVM, PhD, DACVIM, DACVN, University of Tennessee - Knoxville
  • C.A. Osborne
  • J.P. Lulich
  • J.M. Kruger
  • S.L. Sanderson
  • L.A. Koehler
  • L.K. Ulrich
Abstract

Etiopathologic factors predisposing to urate lithogenesis in Dalmatian and non-Dalmatian dogs represent diverse pathologic and/or physiologic processes involving purine nucleotide and ammonia synthesis, biodegradation, and excretion. Predisposing factors for urate urolith formation include hyperuricemia, hyperammonemia, hyperuricosuria, hyperammonuria, aciduria, and genetic predisposition. Medical therapy of dogs forming urate uroliths should be directed at modifying these predisposing factors through dietary modification, administration of allopurinol, and/or surgical correction of portovascular anomalies if present. The precise mechanisms resulting in urate urolith formation in dogs have not been determined.

Disciplines
Publication Date
1999
Citation Information
Joe Bartges, C.A. Osborne, J.P. Lulich, J.M. Kruger, et al.. "Canine urate urolithiasis" Veterinary Clinic North American Small Animal Practice Vol. 29 (1999)
Available at: http://works.bepress.com/joe_bartges/80/