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Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P‑Imidazolides and Microwaves
Organic Letters (2012)
  • Malwina Strenkowska
  • Przemyslaw Wanat
  • Marcin Ziemniak
  • Joanna Kowalska
  • Jacek Jemielity
Abstract

We describe a general method for the elongation of nucleoside oligophosphate chains by means of cyanoethyl (CE) phosphorimidazolides. Though the method requires a phosphorylation and subsequent deprotection reaction, both steps could be achieved in one pot without isolation/purification of the initial phosphorylation product. We have also found that pyrophosphate bond formation by this method is significantly accelerated by microwave irradiation.

Publication Date
2012
Citation Information
Malwina Strenkowska, Przemyslaw Wanat, Marcin Ziemniak, Joanna Kowalska, et al.. "Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P‑Imidazolides and Microwaves" Organic Letters (2012)
Available at: http://works.bepress.com/joanna_kowalska/12/