To date, there are few studies that use rigorous research designs to evaluate interventions designed to address the needs of homeless children. Strengths and noteworthy findings as well as the challenges and limitations of this literature are summarized. The studies reviewed in this chapter represent laudable efforts on the part of researchers, practitioners, and community partners to engage in intervention studies with the challenging and understudied population of children in families experiencing homelessness. However, within the guidelines of the What Works Clearinghouse (WWC) standards for evidence based practices, none of the interventions represented in these studies have sufficient evidence to be rated as having Positive Effects. Most often, this is due to lack of quality evidence that evaluates the program outcomes. Policymakers, funding agencies, researchers, clinicians, and community practitioners can expand the evidence base for interventions with homeless children through understanding what constitutes quality evaluations and supporting high-quality research. This chapter concludes with recommendations for building a robust and rigorous evidence base of what works to allow stakeholders to improve the well-being of at-risk children, bettering their lives through increasingly effective and efficient programs.