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Article
Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population
ECU Publications Post 2013
  • Yu-Xiang Yan
  • Li-Jian Wu
  • Jie Zhang
  • Shuo Wang
  • Wei Wang, Edith Cowan University
  • Jing Dong
  • Yan He
Publication Date
1-1-2015
Document Type
Journal Article
Publisher
Japan Endocrine Society
School
School of Medical and Health Sciences
RAS ID
19920
Comments

Originally published as: Yan, Y., We, L., Wang, S., Wang, W., Dong, J., & He, Y. (2015). Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population. Endocrine Journal, 62(10). 887-896. . Original article available here

Abstract

MicroRNA (miRNA) related genetic variation may change miRNA binding affinity and mRNA expression levels of the target genes, thus leading to altered metabolic parameters. This study explored the influence of let-7 related single nucleotide polymorphisms (SNPs) on individual susceptibility to metabolic syndrome (MetS) in a Chinese population. Seven SNPs located at the pri-let-7 gene region, pre-let-7 gene region or 3’-UTR of the KRAS gene were selected. The SNPs were genotyped in 503 MetS patients and 529 normal controls using the high-throughput Sequenom genotyping platform. Unconditional logistic regression analysis was utilized to estimate the association between these SNPs and the risk of MetS. There are three SNPs significantly associated with MetS. The A allele of rs17276588 was associated with an increased risk effect for MetS (Adjusted OR=1.75, 95%CI 1.37-2.25, P

DOI
10.1507/endocrj.EJ15-0236
Citation Information
Yu-Xiang Yan, Li-Jian Wu, Jie Zhang, Shuo Wang, et al.. "Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population" Kyoto, Japan(2015)
Available at: http://works.bepress.com/jing_dong/9/