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Article
Local and Global Stabilities of a Viral Dynamics Model with Infection-Age and Immune Response
Journal of Dynamics and Differential Equations
  • Jianhua Pang, Guangxi University of Science and Technology - Liuzhao, China
  • Jing Chen, University of Miami
  • Zijian Liu, Chongqing Jiaotong University - China
  • Ping Bi, East China Normal University - Shanghai, China
  • Shigui Ruan, University of Miami
Document Type
Article
Publication Date
4-28-2018
Keywords
  • Age-structured model,
  • Viral dynamics,
  • Integrated solution,
  • Liapunov functional,
  • Local and global stabilities
Abstract

In this paper, we construct an infection-age model to study the interaction between viruses and the immune system within the host. In the model, the mortality rate of infected cells, the rate that cytotoxic T lymphocytes (CTL) kill infected cells, the rate that infected cells produce new virus, and the CTL proliferate rate may depend on the infection-age. The basic reproduction number and the threshold for the existence of steady states are obtained. Local stability of both the infection-free and infection steady states is studied by analyzing the linearized systems. Global stability of the infection-free steady state is obtained by investigating a renewal integral equation and global stability of the infection steady state is obtained by constructing a Liapunov functional. Numerical simulations are presented to verify the theoretical results.

Comments

©Springer Science+Business Media, LLC, part of Springer Nature 2018

Additional Comments
National Natural Science Foundation of China grant #s: 11401117, 11401060, 11401217, 11771168; Improvement Project for Young Teachers of Guangxi Province grant #: KY2016YB246; NSF grant #: DMS-1412454
DOI
10.1007/s10884-018-9663-1
Citation Information
Jianhua Pang, Jing Chen, Zijian Liu, Ping Bi, et al.. "Local and Global Stabilities of a Viral Dynamics Model with Infection-Age and Immune Response" Journal of Dynamics and Differential Equations (2018) p. 1 - 21 ISSN: 1040-7294
Available at: http://works.bepress.com/jing-chen/8/