Using data compiled by the United States Sentencing Commission, we examine the independent and joint effects of race/ethnicity, gender, and age on sentencing decisions in U.S. federal courts. We find that Hispanics and blacks, males, and younger defendants receive harsher sentences than whites, females, and older defendants after controlling for important legal and contextual factors. When these effects are examined in combination, young Hispanic male defendants have the highest odds of incarceration and young black male defendants receive the longest sentences. The findings show considerable variation in the sentencing outcomes of defendants depending on their relative social-structural position in society, and that particularly harsh punishments are focused disproportionately on the youngest Hispanic and black male defendants. Our results reinforce the idea that researchers need to consider the combined impact of multiple defendant statuses on sentencing outcomes because joint effects are considerably larger than the effects of any one defendant characteristic.