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Article
A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites
Orthopedics and Physical Rehabilitation Publications and Presentations
  • Jie Song, University of Massachusetts Medical School
  • Eduardo Saiz, Lawrence Berkeley National Laboratory
  • Carolyn R. Bertozzi, University of California
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation
Date
1-30-2003
Document Type
Article
Medical Subject Headings
Biocompatible Materials; Bone Substitutes; Durapatite; Hydrogels; Polyhydroxyethyl Methacrylate; X-Ray Diffraction
Abstract
As a first step toward the design and fabrication of biomimetic bonelike composite materials, we have developed a template-driven nucleation and mineral growth process for the high-affinity integration of hydroxyapatite with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of cross-linked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface, along with extensive calcification of the hydrogel interior. Robust surface mineral layers a few microns thick were obtained. The same mineralization technique, when applied to a hydrogel that is less prone to surface hydrolysis, led to distinctly different mineralization patterns, in terms of both the extent of mineralization and the crystallinity of the apatite grown on the hydrogel surface. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral-hydrogel interfacial adhesion strength.
Rights and Permissions
Citation: J Am Chem Soc. 2003 Feb 5;125(5):1236-43. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
12553825
Citation Information
Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. "A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites" Vol. 125 Iss. 5 (2003) ISSN: 0002-7863 (Linking)
Available at: http://works.bepress.com/jie_song/30/