A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates)Orthopedics and Physical Rehabilitation Publications and Presentations
UMMS AffiliationDepartment of Orthopedics and Physical Rehabilitation; Department of Cell Biology
AbstractDespite the increasing demands for functional degradable biomaterials, strategies for generating materials with modular compositions and well-defined functionalities from common building blocks are still lacking. Here we report an azido-functionalized cyclic carbonate monomer, AzDXO, that exhibited controlled/"living" ring-opening polymerization kinetics under the catalysis of 1,8-diazabicyclo[5.4.0]-undec-7-ene. Homopolymerization of AzDXO and copolymerization of AzDXO with lactide resulted in polycarbonate and poly(ester-carbonates) with well-defined composition and narrow polydispersity. Further side-chain functionalizations of these polymers were accomplished under facile conditions via copper-catalyzed or copper-free strain-promoted azido-alkyne cyclcoaddition. This versatile monomer building block, obtainable in two steps without tedious purifications, provides a practical solution to the preparation of well-defined functional polycarbonates and poly(ester-carbonates).
DOI of Published Version10.1021/ma200021m
SourceMacromolecules. 2011 Apr 26;44(8):2660-2667. Link to article on publisher's site
Related ResourcesLink to Article in PubMed
Citation InformationJianwen Xu, Fioleda Prifti and Jie Song. "A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates)" Vol. 44 Iss. 8 (2011) ISSN: 0024-9297 (Linking)
Available at: http://works.bepress.com/jie_song/29/