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Article
A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates)
Orthopedics and Physical Rehabilitation Publications and Presentations
  • Jianwen Xu, University of Massachusetts Medical School
  • Fioleda Prifti, University of Massachusetts Medical School
  • Jie Song, University of Massachusetts Medical School
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation; Department of Cell Biology
Publication Date
4-26-2011
Document Type
Article
Subjects
Biocompatible Materials
Abstract
Despite the increasing demands for functional degradable biomaterials, strategies for generating materials with modular compositions and well-defined functionalities from common building blocks are still lacking. Here we report an azido-functionalized cyclic carbonate monomer, AzDXO, that exhibited controlled/"living" ring-opening polymerization kinetics under the catalysis of 1,8-diazabicyclo[5.4.0]-undec-7-ene. Homopolymerization of AzDXO and copolymerization of AzDXO with lactide resulted in polycarbonate and poly(ester-carbonates) with well-defined composition and narrow polydispersity. Further side-chain functionalizations of these polymers were accomplished under facile conditions via copper-catalyzed or copper-free strain-promoted azido-alkyne cyclcoaddition. This versatile monomer building block, obtainable in two steps without tedious purifications, provides a practical solution to the preparation of well-defined functional polycarbonates and poly(ester-carbonates).
DOI of Published Version
10.1021/ma200021m
Source
Macromolecules. 2011 Apr 26;44(8):2660-2667. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
21686053
Citation Information
Jianwen Xu, Fioleda Prifti and Jie Song. "A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates)" Vol. 44 Iss. 8 (2011) ISSN: 0024-9297 (Linking)
Available at: http://works.bepress.com/jie_song/29/