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(alpha-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging
Orthopedics and Physical Rehabilitation Publications and Presentations
  • Guanying Chen, Harbin Institute of Technology
  • Jie Shen, University of Massachusetts Medical School
  • Tymish Y. Ohulchansky, University at Buffalo
  • Nayan J. Patel, Roswell Park Cancer Institute
  • Artem Kutikov, University of Massachusetts Medical School
  • Zhipeng Li, University of North Carolina
  • Jie Song, University of Massachusetts Medical School
  • Ravindra K. Pandey, Roswell Park Cancer Institute
  • Hans Agren, Royal Institute of Technology
  • Paras N. Prasad, Harbin Institute of Technology
  • Gang Han, University of Massachusetts Medical School
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation
Date
9-1-2012
Document Type
Article
Medical Subject Headings
Animals; Calcium Fluoride; Contrast Media; Femur; Fluorides; Infrared Rays; Materials Testing; Mice; Microscopy, Fluorescence; Molecular Conformation; Muscle, Skeletal; Nanoparticles; Particle Size; Porosity; Rats; Swine; Yttrium
Abstract
We describe the development of novel and biocompatible core/shell (alpha-NaYbF(4):Tm(3+))/CaF(2) nanoparticles that exhibit highly efficient NIR(in)-NIR(out) upconversion (UC) for high contrast and deep bioimaging. When excited at ~980 nm, these nanoparticles emit photoluminescence (PL) peaked at ~800 nm. The quantum yield of this UC PL under low power density excitation (~0.3 W/cm(2)) is 0.6 +/- 0.1%. This high UC PL efficiency is realized by suppressing surface quenching effects via heteroepitaxial growth of a biocompatible CaF(2) shell, which results in a 35-fold increase in the intensity of UC PL from the core. Small-animal whole-body UC PL imaging with exceptional contrast (signal-to-background ratio of 310) is shown using BALB/c mice intravenously injected with aqueously dispersed nanoparticles (700 pmol/kg). High-contrast UC PL imaging of deep tissues is also demonstrated, using a nanoparticle-loaded synthetic fibrous mesh wrapped around rat femoral bone and a cuvette with nanoparticle aqueous dispersion covered with a 3.2 cm thick animal tissue (pork).
Rights and Permissions
Citation: ACS Nano. 2012 Sep 25;6(9):8280-7. Epub 2012 Sep 4. Link to article on publisher's site
Comments

Co-author Artem B. Kutikov is a doctoral student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
22928629
Citation Information
Guanying Chen, Jie Shen, Tymish Y. Ohulchansky, Nayan J. Patel, et al.. "(alpha-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging" Vol. 6 Iss. 9 (2012) ISSN: 1936-0851 (Linking)
Available at: http://works.bepress.com/jie_song/27/