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Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone
Orthopedics and Physical Rehabilitation Publications and Presentations
  • Jie Song, University of Massachusetts Medical School
  • Viengkham Malathong, University of California
  • Carolyn R. Bertozzi, University of California
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation; Department of Cell Biology
Publication Date
Document Type
Acrylamides; Bone Substitutes; Durapatite; Hydrogels; Polyhydroxyethyl Methacrylate

The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Cross-linked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite. Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bonelike composites and suggests a potential role for hydroxylated collagen proteins in bone mineralization.

DOI of Published Version
J Am Chem Soc. 2005 Mar 16;127(10):3366-72. Link to article on publisher's site

At the time of publication, Jie Song was not yet affiliated with the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Jie Song, Viengkham Malathong and Carolyn R. Bertozzi. "Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone" Vol. 127 Iss. 10 (2005) ISSN: 0002-7863 (Linking)
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