Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial boneOrthopedics and Physical Rehabilitation Publications and Presentations
UMMS AffiliationDepartment of Orthopedics and Physical Rehabilitation; Department of Cell Biology
Medical Subject HeadingsAcrylamides; Bone Substitutes; Durapatite; Hydrogels; Polyhydroxyethyl Methacrylate
AbstractThe controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Cross-linked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite. Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bonelike composites and suggests a potential role for hydroxylated collagen proteins in bone mineralization.
Rights and PermissionsCitation: J Am Chem Soc. 2005 Mar 16;127(10):3366-72. Link to article on publisher's site
Related ResourcesLink to Article in PubMed
Citation InformationJie Song, Viengkham Malathong and Carolyn R. Bertozzi. "Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone" Vol. 127 Iss. 10 (2005) ISSN: 0002-7863 (Linking)
Available at: http://works.bepress.com/jie_song/18/