Corrosion in aircraft structures and systems persists to pose significant problem in the aircraft industry. It affects both the aircraft structures and all the wiring systems including data transmission lines at the points of mechanical damage (missing or damaged insulation and jacket materials) and connections. Reliability of data transmission through aircraft data transmission lines (ATDL) is essential for maintaining performance capability and safety of flights. Unfortunately, there is no existing method for detecting corrosion and predicting its effect for wiring systems including ADTL. Detecting corrosion and predicting its effect on time would prevent unexpected system failures and catastrophes. This paper presents novel experimental method that has been employed, for the first time, to detect and study the effect of localized corrosion process on reflected and transmitted power signals passing through locally corroded ADTL with mechanically induced damage. ADTL with three types of induced damage were corroded in a Q-Fog cyclic accelerated corrosion chamber for over 14 weeks (2352 h) using ASTM G85-A5 Prohesion test that resembles the environment of aircraft operation. Cable specimens were taken out every week and investigated by measuring transmitted and reflected power signals passing through the corroded ADTL using Vector Network Analyzer (VNA), where signals from 0 to 6 GHz were swept into the ADTL. Reflected and transmitted power signals (S11 and S21 respectively) were acquired in time domain and processed in MATLAB. Analysis of results show that corrosion effect is not arbitrary and can be tracked over time and predicted. Reflected signal peak width changed over time of corrosion exposure and is proportional to corrosion propagation width inside the ADTL. It is also observed that corrosion induced extra distortion of signals passing through the corroded damage region. The results are very promising for detecting corrosion and predicting its effect in ADTL.